Starting the second round sharing fourth place and four off the overnight lead, Wilson scorched the highly regarded layout in 64, one of only six sub-70 rounds recorded on the day and the best by two shots.
Australian Open runner-up Ash Hall and another Victorian, Aaron Cox, shared second place three shots behind Wilson.
Hall followed a first round 69 with an impressive 66 while Cox backed up an opening 64 of his own with a 71.
A former PGA Trainee of the Year, Wilson made history in 2013 when he became the first Trainee to win an official PGA Tour of Australasia event at the WA PGA Championship in Kalgoorlie.
The 26-year-old has battled injury and form issues since but showed he still has the game to compete in what was virtually a home town tournament.
Wilson grew up in nearby Echuca and said he always looks forward to returning to his old stomping ground to play.
“I grew up at Echuca so it’s great to come up here and support these events,” he said.
“I try to get up here every year if I’m in Australia and I’ll continue to do so because it’s one of the best golf courses we get to play in Australia and I definitely recommend it to anyone who’s around.”
Wilson, who has been disappointed with his recent results on the local Tour, said the venues played this past week were among his favourites in Australia.
“Obviously we’ve just come off a month on Tour and it wasn’t great,” he said.
“I was probably disappointed with my results out there but then you get to come up here and play golf courses as fantastic as these.
“We had Murray Downs to start then Cohuna and three days at this incredible venue. We’re just super lucky, these venues feel like Augusta. It’s great.”
Inspired by the layouts, Wilson said it was his ball-striking which came to the fore on day two on a course that features five par-fives.
“It was a little bit on a string,” he said. “Admittedly there was no wind to contend with and the putts started to drop.
“It was the ball-striking that got me around today. I had a lot of two-putt birdies and we’re lucky there is five par-fives out here as well.”
WEEKEND PINS: 3RD AT ROSSDALE GOLF CLUB (VIC)