Murray - one of 38 amateurs in the 132-person field - fired an opening round of six under par 65 at The Brisbane Golf Club to lead by one shot from NSW golfer Adam Blyth.
Beginning his morning round on the 10th, Murray obliterated the back nine's odd holes with birdies at the 11th, 13th, 15th and 17th to turn in four under.
The 21-year-old added another birdie at the par-four second before his only bogey for the day came at the par-four sixth.
Two late birdies at the seventh and ninth holes gave the Commonwealth Golf Club ace some breathing space at the top of the leaderboard.
Speaking after his round, Murray said some much-needed rest earlier this week was crucial to his fast start.
Former PGA Tour player Rhein Gibson shares third at four under alongside Kevin Yuan and Jordan Zunic.
Another major storyline from Thursday was always going to be the performance of Queensland amateur Becky Kay; the first woman to compete in the history of the Queensland Open.
Playing in the more difficult afternoon conditions, Kay struggled to a five over opening nine before bouncing back on her closing nine to sign for a four over 75.
The 19-year-old recorded her first birdie of the round at the par-four second before adding another at the very next hole with a majestic chip-in.
Back-to-back bogeys at the seventh and eighth for Kay were partially offset by a closing birdie at the par-five ninth.
Want video tips delivered straight to your inbox? Subscribe to iseekgolf.com newsletters.